News 


January 27, 2018. Congratulations to our lab members, Peng Zhao and Peng Wang! Both of them were recognized by the Chinese Association for Science and Technology in Utah with the Outstanding Research Awards. Zhao solely received the first place award. Wang received the second place award. See the two cool awardees receiving at their awards ceremony at YouTube​.
                                                                                                                                                           
January 8, 2018. Peng Wang published in Theranostics a research article describing a total protein-based CTL vaccine carrier. The carrier not only delivers the vaccine to dendritic cells in lymph nodes but also protects the vaccine from undesired degradation in acidic cellular vesicles in dendritic cells. Here is the related research news roundup.

                                                                                                                                                                                                                     

October 2, 2017, Dr. Shuyun Dong published a paper in Molecular Pharmaceutics reporting an new vaccine carrier that facilitated the direct loading of CTL epitopes onto MHC-I complexes on dendritic cell surface and enhanced the epitope-induced responses. This project is NIH-funded.

                                                                                                                                                                                                                         

August 28, 2017. Congratulations to Dr. Shuyun Dong and Peng Wang for their recent publication in  Acta Pharmacologica Sinica. These publications summarized recent progress in our lab in development carriers for T cell vaccines.

                                                                                                                                                                                                                          

May 1, 2017, Peng Zhao published a research article in Molecular Pharmaceutics for a recombinant nanoparticle that presented anti-programmed death-1 (PD-1) antibody in a multivalent fashion, which opened a new avenue to deliver and potentiate PD-1 antibody, an important cancer immunotherapeutic.

                                                                                                                                                                                                                          

March 29, 2017.  Congratulations to Peng Zhao for being selected as a 2017-2018 University of Utah Graduate Research Fellow. What an achievement! He will use the fellowship support to explore better immunotherapeutics.

                                                                                                                                                                                                                         

March, 2017.  We received an R21 funding support to explore new approaches to directly load CTL vaccine epitopes  onto MHC class I complex on dendritic cell surfaces. These approaches promise to skip those inefficient intracellular vaccine processing steps in dendritic cells and hence improve the efficacy of CTL vaccines. 

                                                                                                                                                           

April 2016.  Dr. Mingnan Chen and Peng Zhao shared their passion, accomplishments, and future plans of using vaccines and iTEP vaccine carriers to fight cancer and infectious diseases on The Scope, the University of Utah Health Sciences Radio. Turn on your speaker! 
                                                                                                                                                                                                                           April 25, 2016. Peng Zhao won the Fox Award! The Jeffery Fox Award recognizes a graduate student of Utah Pharmaceutics yearly for his or her excellence in academic achievements and services to the department. This award was established to honor Dr. Jeffery Fox for his dedication and care to the department. Peng was selected for exemplifying the spirit of Jeffery Fox. Way to go, Peng!                                                                                                                                                                                                                                                             

 April 6, 2016. Congratulations to Peng Zhao and Dr. Shuyun Dong! Their co-authored manuscript, entitled "An iTEP-salinomycin nanoparticle that specifically and effectively inhibits metastases of 4T1 orthotopic breast tumors" was published online by Biomaterials .  Here is a linker for the PDF document of the paper. We are thankful to our collaborators Mr. Guiquan Xia and Dr. Zhong-xing Jiang. We also appreciate technical and equipment supports from Professor Jindrich (Henry) Kopecek's and Sung Wan Kim's  groups.

                                                                                                                                                           

Februa​ry 29, 2016. Peng Wang presented his research at the department seminar, which was well-received. Here is a flyer of his seminar entitled "Multifunctional vaccine carrier enhancing immune response”. 

                                                                                                                                                           
February 8, 2016. Congratulations to Dr. Shuyun Dong! Dr. Dong's manuscript, entitled "A comparison study of iTEP nanoparticle-based CTL vaccine carriers revealed a surprise relationship between the stability and efficiency of the carriers," was accepted for publication by Theranostics.  DOI: 10.7150/thon.14068. 



Chen's Laboratory for Immunotherapeutic Study

UNIVERSITY  OF  UTAH     Department  of  Pharmaceutics

COLLEGE    PHARMACY    and Pharmaceutical Chemistry

OF