UNIVERSITY  OF  UTAH     Department  of  Pharmaceutics

COLLEGE    PHARMACY    and Pharmaceutical Chemistry


Chen's Laboratory for Immunotherapeutic Study

​​​​​Publications (Link to My Bibliography)


Zhao P, Wang P, Dong S, Zhou Z, Cao Y, Yagita H, He X, Zheng S, Fisher S, Fujinami R, and Chen M (2019). Depletion of PD-1-positive cells ameliorates autoimmune disease. Nature Biomedical Engineering, online

Wang P, Dong S, Zhao P, He X, and Chen M (2018). Direct loading of CTL epitopes onto MHC class I complexes on dendritic cell surface in vivo. Biomaterials, 182, 92-103


Wang P, Zhao P, Dong S, Xu T, He X, and Chen M (2018). An Albumin Binding Polypeptide both Targets Cytotoxic T Lymphocyte Vaccines to Lymph Nodes and Boosts Vaccine Presentation by Dendritic Cells. Theranostics, 8(1), 223-236


Dong S, Wang P, Zhao P, Chen M (2017). Direct Loading of iTEP-Delivered CTL Epitope onto MHC Class I Complexes on the Dendritic Cell Surface. Molecular Pharmaceutics, 14(10), 3312-3321


Zhao P, Atanackovic D, Dong S, Yagita H, He X, Chen M (2017). An Anti-Programmed Death-1 Antibody (αPD-1) Fusion Protein That Self-Assembles into a Multivalent and Functional αPD-1 Nanoparticle. Molecular Pharmaceutics, 14(5), 1494-1500.


Dong S, Xu T, Wang P, Zhao P, Chen M (2017). Engineering of a self-adjuvanted iTEP-delivered CTL vaccine. Acta Pharmacologica Sinica, 38(6), 914-923.


Zhao P, Xia G, Dong S, Jiang Z, & Chen, M. (2016) An iTEP-salinomycin nanoparticle that specifically and effectively inhibits metastases of 4T1 orthotopic breast tumors. Biomaterials. Vol93 p1-9.


Shi Q, Li Y, Bo S, Li X. Zhao P, Liu Q, Yang Z, Cong H, Deng H, Chen M, Chen S, Zhou X, Ding H, and Jiang Z. (2016) Discovery of a 19F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells. Chemical Communications. Vol52 p5136-5139


Dong S, Xu T, Parent KN, & Chen M. (2016) A comparison study of iTEP nanoparticle-based CTL vaccine carriers revealed a surprise relationship between the stability and efficacy of the carriers. Theranostics. Vol. 6(5), p666-678. DOI: 10.7150/thno.14068 


Cho S*, Dong S*, Parent KN, & Chen M. (2016). Immune-tolerant elastin-like polypeptides (iTEPs) and their application as CTL vaccine carriers. Journal of Drug Targeting. Vol.24, p328-339. PMID:26307138 (* Equal contributions)


Mastria EM*, Chen M*, McDaniel JR, Li X, Hyun J, Dewhirst MW, & Chilkoti A. (2015). Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma. Journal of Controlled Release. Vol.8, p993-999. PMID:19898461 (* Equal contributions)


Zhang J, Kale V, & Chen M. (2015). Gene-Directed Enzyme Prodrug Therapy. The AAPS journal, 17(1), 102-110. 


Zhao P, Dong S, Bhattacharyya J, and Chen M. (2014) iTEP Nanoparticle-Delivered  Salinomycin Displays an Enhanced Toxicity to Cancer Stem Cells in Orthotopic Breast Tumors. Mol Pharm. Vol.11, p2703-2712. PMID: 24960465. 


Chen M, McDaniel JR, MacKay JA, & Chilkoti A. (2011) Nanoscale Self-Assembly for Delivery of Therapeutics and Imaging Agents. Technology and innovation. Vol.13, p5-25. PMID: 24077873 


Liu W, MacKay JA, Dreher MR, Chen M, McDaniel JR, ... & Chilkoti A. (2010) Injectable intratumoral depot of thermally responsive polypeptide–radionuclide conjugates delays tumor progression in a mouse model. Journal of Controlled Release. Vol.144, p2-9. PMID: 20117157 


MacKay JA*, Chen M*, Liu W, McDaniel J, Simnick A, Chilkoti A (2009). Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumors after a single injection. Nature Materials. Vol.8, p993-999. (*Equal contributions)   


Sadegh-Nasseri S, Chen M, Narayan K, Bouvier M (2008). The convergent roles of tapasin and HLA-DM in antigen presentation. Trends Immunol, 29, 141-147.


Chen M, Bouvier M (2007). Analysis of interactions in a tapasin/class I complex provides a mechanism for peptide selection. Recommended as a “Must Read” paper by Faculty of 1000 Biology. EMBO J, 26, 1681-1690. 


Tan, Y., Chen, M., Li, Z., Mabuchi, K., & Bouvier, M. (2006). The calcium-and zinc-responsive regions of calreticulin reside strictly in the N-/C-domain.Biochimica et Biophysica Acta (BBA)-General Subjects, 1760(5), 745-753.  


Chen, M., Stafford, W. F., Diedrich, G., Khan, A., & Bouvier, M. (2002). A characterization of the lumenal region of human tapasin reveals the presence of two structural domains. Biochemistry, 41(49), 14539-14545.